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Prolonged treatment of neuroblastoma cell lines with standard chemotherapy agents, etoposide or doxorubicin showed increased levels and synthesis of GSH, increased expression of -glutamyl-cysteinyl ligase, and decreased depletion of GSH [58, 65]

RSL3 inhibits mTOR signaling in thyroid cancer cells The mTOR signaling pathway has recently been implicated in counteracting ferroptosis by regulating ROS production 20 , therefore, it was important to examine the effects of RSL3 on mTOR signaling pathway and its downstream proteins and whether inactivation of mTOR pathway signaling will occur in thyroid cancer cells with GPX4 inhibition

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[DOI] [PMC free article] [PubMed] [Google Scholar] 147.Kim SH, Hwang WJ, Cho JS & Kang DR Attributable risk of lung cancer deaths due to indoor radon exposure

Apparently, this antioxidant is not easily absorbed into the cells of our epithelium (top layer of skin), where melanin is naturally produced